HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 53863499, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | (R)-2-((tert-Butoxycarbonyl)amino)-5-phenylpentanoic acid | HCID 7016821 | — |
| Reactant | HCID 54470166 | HCID 54470166 | — |
| Product | HCID 53863499 | HCID 53863499 | 69.7% |
Reaction Steps
The intermediate from Step A (120 mg, 0.33 1 mmol) was treated with 4N HCl as in Example 85, Step A. The residue was reacted with the compound prepared in Example 73, Step B (97 mg, 0.33 mmol), EDC (94.7 mg. 0.496 mmol), HOBT (67 mg, 0.49 mmol) and NMM (0.076 ml, 0.66 mmol) according to the procedure described for Example 1, Step A. The title compound (123 mg, 0.23 mmol) was obtained as a white solid after flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05578593 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-3b6a8d27ad7a4b89a4434850c1e6b7f6 |
| Source note | uspto-grants-1996_11 |