Phosphorus sulfide (P2S5) → HCID 131712885, compound

Participants

Reaction Conditions

Reaction Steps

To 3.0 g. N-benzoyl-L-valine, methyl ester dissolved in 50 ml benzene was added 0.56 g. phosphorus pentasulfide in one portion at 20° C. The mixture was refluxed for about 4 hours, cooled to about 20° C. and filtered. The resulting oil which was collected was washed with methylene chloride and filtered. The combined filtrates were concentrated under vacuum to yield a yellow oil. Column chromatography with silica gel and a hexane-ethyl acetate solvent system gave 1.89 g. (59%) of a yellow oil.

Provenance & Evidence