Dimethylamine → HCID 12892986, compound

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Reaction Steps

In 100 ml of acetonitrile is dissolved 3.0 g of N-(4-chlorophenyl)-3,4,5,6-tetrahydrophthalimide. To the solution is added 1.5 g of a 40% aqueous dimethylamine solution under stirring at room temperature, followed by further stirring for 30 minutes. The solution is concentrated to dryness under reduced pressure, the resulting oily substance is dissolved in 50 ml of ether and the solution is dried with sodium sulfate. The ether layer is concentrated to dryness under reduced pressure and the resultant oily substance is allowed to crystallize by adding 50 ml of n-hexane thereto. The resultant crystals are recovered by filtration and washed with a small amount of n-hexane, whereby to yield 2.5 g of the subject compound.

Provenance & Evidence