Chlorosuccinimide → HCID 20515893, compound

Participants

Reaction Steps

0.56 g (2.6 mmol) of 4,5-dihydro-5-methyl-6H-imidazo[1,5-a]pyrido[2,3-f][1,4]diazepin-6-one and 0.35 g (2.6 mmol) of N-chlorosuccinimide are treated with 10 ml of dimethylformamide and the mixture is stirred at 90°-100° for 30 minutes. After evaporation to dryness, the residue is chromatographed on silica gel using chloroform containing 4% methanol for the elution. After recrystallization from ethyl acetate, there is obtained 3-chloro-4,5-dihydro-5-methyl-6H-imidazo[1,5-a]pyrido[2,3-f][1,4]diazepin-6-one of melting point 247°-248°.

Provenance & Evidence