Hydroxylamine → HCID 178512697, compound

Participants

Reaction Steps

In 35 ml of methanol was dissolved 4.72 g of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and then 25 ml of a methanol solution of free hydroxylamine prepared by treating 1.2 g of hydroxylamine hydrochloride with 0.93 g of sodium methoxide was added to the solution. After stirring the mixture for 2 hours at room temperature, the solvent was distilled off under reduced pressure and the residue formed was purified by a column chromatography using a mixed solvent of chloroform and methanol as a developing solvent and recrystallized from methanol-acetone to provide 1.3 g of 3-[(2-guanidinothiazol-4-yl)methylthio]propionamidoxime. The product has the following physicochemical properties:

Provenance & Evidence