Cyanamide → HCID 178485175, compound

Participants

Reaction Steps

In 30 ml of ethanol was dissolved 6.4 g of methyl 3-(2-methylguanidinothiazol-4-ylmethylthio)propionimidate and after adding thereto 0.9 g of cyanamide and stirring the mixture for 2 hours at room temperature, the solvent was distilled off under reduced pressure. Then, the residue obtained was purified by column chromatography using a mixture of chloroform and methanol as the developing solvent and recrystallized from ethanol to provide 2.0 g of N-cyano-3-(2-methylguanidinothiazol-4-ylmethylthio)propionamidine showing a melting point of 144°-145° C.

Provenance & Evidence