反应详情

In a mixture of 30 ml of ethanol and 30 ml of water was dissolved 5.0 g of methyl 3-(2-guanidinothiazol-4-ylmethylthio)propionimidate and after allowing to stand the solution for 20 hours at 40° C., the solvent was distilled off under reduced pressure. The residue formed was purified by a column chromatography using a mixture of chloroform and methanol and recrystallized from methanol to provide 3.2 g 3-(2-guanidinothiazol-4-ylmethylthio)propionamide showing a melting point of 193°-194° C. (decompd.).

1. customfor 20 hours
2. customat 40° C.
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residue formed
5. customwas purified by a column chromatography
6. additiona mixture of chloroform and methanol
7. customrecrystallized from methanol