Cyanamide → HCID 178512321, compound

Participants

Reaction Steps

In 10 ml of methanol solution of 2.5 g of methyl 5-(2-guanidinothiazol-4-yl)pentanoimidate was added 0.6 g cyanamide, and the solution was stirred at room temperature for 1.5 hour. The solvent was distilled off, and to the residue was added 10 ml of acetone. The precipitated crystals were filtered off and the product was purified by using dimethylformamide-water. The purified product was dissolved in a mixture of 0.7 ml of acetic acid, 8 ml of ethanol and 16 ml of water, to the solution 11.6 ml of N-NaOH solution was added. The precipitated crystals were collected by filtration to provide 1.9 g of N-cyano-5-(2-guanidinothiazol-4-yl)pentanoamidine.

Provenance & Evidence