Methyl 5-acetylsalicylate → JR-13533, Methyl 5-ethyl-2-hydroxybenzoate, 97%

Participants

Reaction Steps

Methyl 5-acetylsalicylate (10.0 g) was hydrogenated in the presence of 5% Pd-C (1.0 g) in ethyl acetate (200 ml) containing 70% HClO4 (2 ml) at room temperature under usual pressure of H2 gas with stirring. The catalyst was filtered off and the filtrate was evaporated in vacuo to give crude methyl 5-ethylsalicylate as pale brown oil.

Provenance & Evidence