Acetic Acid → HCID 12767920, compound

HRID 1902248Notes

Reaction equation

HRID 1902248 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:8]3([CH2:10][CH2:9]3)[S:7][C:6]=2[CH:13]=1.[C:14](O)(=[O:16])[CH3:15]>C(OC(=O)C)(=O)C>[C:14]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:8]3([CH2:10][CH2:9]3)[S:7][C:6]=2[CH:13]=1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 12767919HCID 12767919, compound

Product 1

HCID 12767920HCID 12767920, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

In 2 ml of acetic acid and 2 ml of acetic anhydride was dissolved 9.5 mg of 6-aminospiro[benzo[b]thiophene-2(3H),1'-cyclopropan]-3-one as obtained in Example 6, and the solution was stirred at room temperature for 10 minutes. The reaction solution was evaporated to dryness under reduced pressure, and the residue was chromatographed on a column of silica gel. Recrystallization of the resultant crude crystals from ethanol-water (1:2) yielded colorless needles of 6-acetylaminospiro[benzo[b]thiophene-2(3H),1'-cyclopropan]-3-one. Melting point: 195°-196.5° C.

Workup

  1. customas obtained in Example 6
  2. customThe reaction solution was evaporated to dryness under reduced pressure
  3. customthe residue was chromatographed on a column of silica gel
  4. customRecrystallization of the resultant crude crystals from ethanol-water (1:2)

Sources & evidence

ORD record
ord-b5f969124ca54161a81783fd9e9f8721
Source dataset
uspto-grants-1982_12
Patent number
US04362740

Reaction notes

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