HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → trans-3-[(4-Fluorophenyl)methyl]-1-indanyl cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | trans-3-[(4-Fluorophenyl)methyl]-1-indanol | HCID 70477161 | — |
| Reactant | cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride | HCID 86737382 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | trans-3-[(4-Fluorophenyl)methyl]-1-indanyl cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate | HCID 86738661 | 86.7% |
Reaction Steps
In the manner of Example 4, the reaction of 1.00 g (0.004 mole) of trans-3-[(4-fluorophenyl)methyl]-1-indanol (96% trans, 4% cis) and 1.07 g (0.004 mole) of cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride in the presence of 0.32 g (0.004 mole) of pyridine and 50 mL of toluene gave 1.62 g of trans-3-[(4-fluorophenyl)-methyl]-1-indanyl cis-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate. The ir and nmr spectra were consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04362744 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-72949758340846b7b492b72a902ee048 |
| Source note | uspto-grants-1982_12 |