HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Reactant | 4-Amino-2-(4-phthalimidobutyl)pyrimidine | HCID 20450337 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)pyrimidine | HCID 54214531 | 69.8% |
Reaction Steps
A mixture of 4-amino-2-(4-phthalimidobutyl)-pyrimidine (1 g.), 2,2,2-trifluoroethylisothiocyanate (1 g.) and acetonitrile was stirred at 70° for 18 hours. The mixture was diluted with acetonitrile (10 ml.), cooled in ice and then filtered to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-(4-phthalimidobutyl)-pyrimidine (1.03 g.), m.p. 204°-205°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04362728 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-41a6046fd5174352b59c9c98e757aefc |
| Source note | uspto-grants-1982_12 |