HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-isothiocyanatoethane → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Reactant | 4-Amino-2-[(2-phthalimidoethyl)thiomethyl)pyrimidine | HCID 21298818 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine | HCID 53848275 | 62.6% |
Reaction Steps
A mixture of 4-amino-2-[(2-phthalimidoethyl)-thiomethyl]pyrimidine (5.9 g.), 2,2,2-trifluoroethylisothiocyanate (3.9 g.) and acetonitrile (20 ml.) was stirred at 70° for 72 hours. The reaction mixture was cooled and the crystalline precipitate collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine (5.35 g.), m.p. 178°-179°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04362728 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-a99f7e83a0d546a8b560a2b473070322 |
| Source note | uspto-grants-1982_12 |