Ammonia → 4-[2-(2,2,2-Trifluoroethyl)-guanidino]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine

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Reaction Steps

A mixture of 4-[3-(2,2,2-trifluoroethyl)-thioureido]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine (6.8 g.), dimethylformamide (30 ml.), saturated ethanolic ammonia (5 ml.) and yellow mercuric oxide (6.5 g.) was stirred at room temperature for 2 hours and then filtered. The filtrate was evaporated to dryness and the residue triturated with ether and filtered to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-[(2-phthalimidoethyl)thiomethyl]pyrimidine (5.6 g.), m.p. 167°-168° after crystallisation from ethanol.

Provenance & Evidence