HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylthio-1-methylamino-2-nitroethylene → 1-[3-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-ylthio)propylamino]-1-methylamino-2-nitroethylene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| Reactant | 4-[2-(2,2,2-Trifluoroethyl)guanidino]-2-(3-aminopropylthio)pyrimidine | HCID 21298711 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[3-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-ylthio)propylamino]-1-methylamino-2-nitroethylene | HCID 70417946 | 26.8% |
Reaction Steps
A solution of 4-[2-(2,2,2-trifluoroethyl)-guanidino]-2-(3-aminopropylthio)pyrimidine (0.31 g.) in acetonitrile (5 ml.) was treated with 1-methylamino-1-methylthio-2-nitroethylene (0.15 g.) and the mixture heated under reflux for 18 hours. The hot solution was filtered and cooled and the solid which crystallised was collected and recrystallised from ethanol to give 1-[3-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-ylthio)propylamino]-1-methylamino-2-nitroethylene (0.11 g.), m.p. 189°-191°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04362728 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-b5264bd8091c45c19973048c7fbd81c8 |
| Source note | uspto-grants-1982_12 |