反应详情

A mixture of 4-[2-(2,2,2-trifluoroethyl)-guanidino]-2-methylsulphinylpyrimidine (0.3 g.) and 1,3-diaminopropane (1 ml.) was heated to 90° for 3 hours. The mixture was evaporated to dryness and the residue taken up in 2 N aqueous acetic acid. The solution was washed with ether, basified with 17 N NaOH and the mixture extracted five times with ether. The combined ether extracts were dried and evaporated to dryness to give 4-[2-(2,2,2-trifluoroethyl)guanidino]-2-(3-aminopropylamino)pyrimidine (0.27 g.) which was characterised as the tris hydrogen maleate, m.p. 159° after recrystallisation from acetone.

1. temperaturewas heated to 90° for 3 hours
2. customThe mixture was evaporated to dryness
3. washThe solution was washed with ether
4. extractionthe mixture extracted five times with ether
5. dry with materialThe combined ether extracts were dried
6. customevaporated to dryness