反应详情

A mixture of 2-[2-(2,2,2-trifluoroethyl)-guanidino]-4-(4-aminobutyl)thiazole (0.45 g.) and 2-chloropyrimidine (0.18 g.) was heated under reflux in acetonitrile (5 ml.) for 16 hours. The reaction mixture was then evaporated to dryness and the residue purified by medium pressure liquid chromatography on silica gel using chloroform/methanol/ammonia 1900:100:5 v/v/v as eluant. The appropriate fraction was evaporated to dryness and the residue recrystallised from acetonitrile to give 2-(4-[2-(2-[2,2,2-trifluoroethyl]guanidino)-thiazol-4-yl]butylamino)pyrimidine (0.29 g.), m.p. 173°-175°.

1. temperaturewas heated
2. customThe reaction mixture was then evaporated to dryness
3. customthe residue purified by medium pressure liquid chromatography on silica gel
4. customThe appropriate fraction was evaporated to dryness
5. customthe residue recrystallised from acetonitrile