反应详情

A solution of 2-[2-(2,2,2-trifluoroethyl)-guanidino]-6-(3-aminopropylthio)pyrazine in warm acetonitrile (15 ml.) was allowed to cool to room temperature. A solution of methylisothiocyanate (0.15 g.) in acetonitrile (1 ml.) was added and the mixture stirred overnight. Evaporation to dryness gave a yellow solid which was recrystallised from a small volume of ethyl acetate to yield 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-[3-(3-methylthioureido)-propylthio]pyrazine (0.32 g.), m.p. 165°-167°.

1. customEvaporation to dryness
2. customgave a yellow solid which
3. customwas recrystallised from a small volume of ethyl acetate