Diclofenac → HCID 70549084, compound

HRID 1902342Notes

Reaction equation

[NH2:1][C:2]1[C:21]([CH2:22][N:23]([CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[CH2:24][CH3:25])=[CH:20][C:5]([C:6]([CH:8]([OH:19])[C@H:9]([C@H:11]([C@@H:13]([C@@H:15]([CH2:17][OH:18])[OH:16])[OH:14])[OH:12])[OH:10])=[O:7])=[CH:4][C:3]=1[Br:32].[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[C:35]=1[NH:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[CH2:48][C:49](O)=[O:50]>>[Cl:33][C:34]1[CH:39]=[CH:38][CH:37]=[C:36]([Cl:40])[C:35]=1[NH:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[CH2:48][C:49]([CH:17]([OH:18])[C@H:15]([C@H:13]([C@@H:11]([C@@H:9]([CH:8]([C:6](=[O:7])[C:5]1[CH:20]=[C:21]([CH2:22][N:23]([CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[CH2:24][CH3:25])[C:2]([NH2:1])=[C:3]([Br:32])[CH:4]=1)[OH:19])[OH:10])[OH:12])[OH:14])[OH:16])=[O:50]

Participants

Reactant 2

HCID 3033Diclofenac

HCID 54119677HCID 54119677, compound

Product 1

HCID 70549084HCID 70549084, compound

Procedure

This compound was prepared from 1-[4-amino-3-bromo-5-(N-ethyl-cyclohexylaminomethyl)-benzoyl]-D-mannitol and 2-[(2,6-dichlorophenyl)-amino]-phenyl-acetic acid analogous to Example 4. Amorphous powder.

Sources & evidence

ORD record: ord-a6c63615d65c4d48a8a7a672863ffde2
Source dataset: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04362738

Reaction notes

Loading…