Diclofenac sodium → HCID 20516372, compound

HRID 1902345Notes

Reaction equation

[NH2:1][C:2]1[C:13]([CH2:14][NH:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:12][C:5]([C:6]([O:8][CH2:9][CH2:10]Cl)=[O:7])=[CH:4][C:3]=1[Br:20].[Cl:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=1[NH:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[CH2:36][C:37]([O-:39])=[O:38].[Na+]>>[NH2:1][C:2]1[C:13]([CH2:14][NH:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:12][C:5]([C:6]([O:8][CH2:9][CH2:10][O:39][C:37](=[O:38])[CH2:36][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=2[NH:29][C:23]2[C:22]([Cl:21])=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:28])=[O:7])=[CH:4][C:3]=1[Br:20]

Participants

Reactant 2

HCID 5018304Diclofenac sodium

HCID 20516359HCID 20516359, compound

Product 1

HCID 20516372HCID 20516372, compound

Procedure

This compound was prepared from 2-(4-amino-3-bromo-5-tert.butylaminomethyl-benzoyloxy)-ethyl chloride and sodium 2-[(2,6-dichlorophenyl)-amino]-phenylacetate analogous to Example 8.

Sources & evidence

ORD record: ord-7b89c069b72b4bd285c59a9bc3959d7e
Source dataset: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04362738

Reaction notes

Loading…