Diclofenac sodium → HCID 20516175, compound

HRID 1902349Notes

Reaction equation

[NH2:1][C:2]1[C:15]([CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:14][C:5]([C:6]([O:8][CH2:9][CH2:10][CH2:11][CH2:12]Cl)=[O:7])=[CH:4][C:3]=1[Br:22].[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=1[NH:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38][C:39]([O-:41])=[O:40].[Na+]>>[NH2:1][C:2]1[C:15]([CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:14][C:5]([C:6]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][O:41][C:39](=[O:40])[CH2:38][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=2[NH:31][C:25]2[C:24]([Cl:23])=[CH:29][CH:28]=[CH:27][C:26]=2[Cl:30])=[O:7])=[CH:4][C:3]=1[Br:22]

Participants

Reactant 2

HCID 5018304Diclofenac sodium

HCID 20516325HCID 20516325, compound

Product 1

HCID 20516175HCID 20516175, compound

Procedure

This compound was prepared from 4-(4-amino-3-bromo-5-pyrrolidinomethyl-benzoyloxy)-n-butyl chloride and sodium 2-[(2,6-dichlorophenyl)-amino]-phenylacetate analogous to Example 8.

Sources & evidence

ORD record: ord-e7186d74deca44aabddc6acad3af9403
Source dataset: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04362738

Reaction notes

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