2-[4-(2-Methylpropenyl)phenyl]propionic Acid → HCID 86738666, compound

HRID 1902375Notes

Reaction equation

HRID 1902375 reaction equation
[Ca:1].[CH3:2][C:3]([CH3:16])=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1>C(O)C>[Ca:1].[CH3:2][C:3]([CH3:16])=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:15])[C:12]([O-:14])=[O:13])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 1563562-[4-(2-Methylpropenyl)phenyl]propionic AcidHCID 5460341Calcium

Product 1

HCID 86738666HCID 86738666, compoundYield 186.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Calcium (0.34 g) in 30 ml of anhydrous ethanol was added to a stirred solution of 2-(4-dimethylvinylphenyl) propionic acid (4 g) in 50 ml of ethanol at room temperature. After refluxing for 1 hour, the clear reaction mixture was cooled and maintained at 0° for 10 hours. The title salt was collected by suction filtration and dried under reduced pressure to yield a white crystalline solid (3.85 g) m.p. 120°-122°. I.R. C=O stretch 1550-1560 cm-1.

Workup

  1. temperatureAfter refluxing for 1 hour
  2. temperaturethe clear reaction mixture was cooled
  3. temperaturemaintained at 0° for 10 hours
  4. filtrationThe title salt was collected by suction filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-de3b1d07354240d999498d4b4f2f5b7b
Source dataset
uspto-grants-1982_12
Patent number
US04362891

Reaction notes

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