Chloroacetone → HCID 12813034, compound

HRID 1902462Notes

Reaction equation

HRID 1902462 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[C:6]([NH2:8])=[S:7].Cl[CH2:17][C:18](=O)[CH3:19]>C1C=CC=CC=1>[CH3:15][O:14][C:10]1[CH:9]=[C:5]([C:6]2[S:7][CH:17]=[C:18]([CH3:19])[N:8]=2)[CH:4]=[C:3]([O:2][CH3:1])[C:11]=1[O:12][CH3:13]

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 3033195Benzamide, thio-3,4,5-trimethoxy-

Product 1

HCID 12813034HCID 12813034, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Into 200 ml of benzene, 22.7 g (0.1 mol) of 3,4,5-trimethoxythiobenzamide and 11.1 g (0.12 mol) of chloroacetone were dissolved, and the solution was heated under a reflux condenser for 5 hours. After cooling to room temperature, the crystals which separated out were collected by filtering and recrystallized from methanol. The product consisting of pale yellow needle-like crystals, and amounting to 16.5 g was thus obtained, melting at 105° to 106.5° C. The yield was 62%.

Workup

  1. temperaturethe solution was heated under a reflux condenser for 5 hours
  2. customthe crystals which separated out
  3. customwere collected
  4. filtrationby filtering
  5. customrecrystallized from methanol
  6. customwas thus obtained

Sources & evidence

ORD record
ord-1f0497539a2a421e947a2f4b85ddb89b
Source dataset
uspto-grants-1982_12
Patent number
US04363813

Reaction notes

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