反应详情

Into 200 ml of benzene, 22.7 g (0.1 mol) of 3,4,5-trimethoxythiobenzamide and 11.1 g (0.12 mol) of chloroacetone were dissolved, and the solution was heated under a reflux condenser for 5 hours. After cooling to room temperature, the crystals which separated out were collected by filtering and recrystallized from methanol. The product consisting of pale yellow needle-like crystals, and amounting to 16.5 g was thus obtained, melting at 105° to 106.5° C. The yield was 62%.

1. temperaturethe solution was heated under a reflux condenser for 5 hours
2. customthe crystals which separated out
3. customwere collected
4. filtrationby filtering
5. customrecrystallized from methanol
6. customwas thus obtained