Hydroxylamine → 1-[4-Methyl-2-(3,4,5-trimethoxyphenyl)-5-thiazolyl]ethanone oxime

Participants

Reaction Steps

Into an ethanolic solution of 3.1 g (0.01 mol) of 2-(3,4,5-trimethoxyphenyl)-4-methyl-5-acetylthiazole obtained in Example 1 dissolved in 50 ml of ethanol, 27 ml of an aqueous 2% solution of sodium hydroxide (0.013 mol) and 0.93 g (0.013 mol) of hydroxylamine hydrochlorinate were added, and the mixture was heated for 3 hours under a reflux condenser. After cooling the mixture to room temperature, the cooled mixture was introduced into 800 ml of iced water.

Provenance & Evidence