Ammonia → HCID 12813043, compound

HRID 1902469Notes

Reaction equation

HRID 1902469 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=2)=[N:8][C:7]=1[CH3:23])=O)C.[NH3:24]>CO>[CH3:22][O:21][C:13]1[CH:12]=[C:11]([C:9]2[S:10][C:6]([C:4]([NH2:24])=[O:3])=[C:7]([CH3:23])[N:8]=2)[CH:16]=[C:15]([O:17][CH3:18])[C:14]=1[O:19][CH3:20]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12813041HCID 12813041, compound

Product 1

HCID 12813043HCID 12813043, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Into 200 ml of methanol, 16.9 g (0.05 mol) of 2-(3,4,5-trimethoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester produced in Example 3 was dissolved, and 25 ml of an aqueous 28% solution of ammonia was added to the solution. The mixture was left at room temperature for 7 days, and then condensed to dryness. The dried residue was recrystallized from a mixture of methanol and water to obtain the object amounting to 10.9 g (yield of 71%) consisting of colourless needle-like crystals melting at 196° to 197° C.

Workup

  1. customcondensed to dryness
  2. customThe dried residue was recrystallized from a mixture of methanol and water
  3. customto obtain the object amounting to 10.9 g (yield of 71%)

Sources & evidence

ORD record
ord-1a56c9f2c22a457f8f4688085ebd9e72
Source dataset
uspto-grants-1982_12
Patent number
US04363813

Reaction notes

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