Sodium hydride → HCID 20515465, compound

Participants

Reaction Conditions

Reaction Steps

The solution of ethyl 3-amino-1,4-dimethyl-1H-pyrrole-2-carboxylate in dimethyl formamide obtained in Example 19 is cooled to 0° C.; 3.0 g of 80% sodium hydride and 14.1 g of 2-fluoronitrobenzene are added thereto with stirring. After removing the ice-bath, the temperature rises to 40° C. and, simultaneously, an evolution of gas can be observed; this evolution subsides after 3 hours. The mixture is stirred overnight, cooled to 0° C.; 100 g of ice and 100 ml of water are then added. The precipitate formed is filtered off and is washed thoroughly with cold (0° C.) methanol. 13.5 g (87%) of the title compound of m.p. 114° C. (from ethanol) are obtained.

Provenance & Evidence