Hydrazine hydrate (1:1) → HCID 20515462, compound

Participants

Reaction Steps

A suspension of Raney nickel in ethanol is added to a warm solution (50° C.) of 80 g of ethyl 1,4-dimethyl-3-(2-nitrophenyl)amino-1H-pyrrole-2-carboxylate and 30 ml of hydrazine hydrate in 2 l of ethanol in such portions that a temperature of 70° C. is not exceeded. After 45 minutes nitrogen evolution is no longer observed when Raney nickel is added. The Raney nickel is filtered off hot and is washed with ethanol. After concentration of the filtrate, 58 g (82%) of the title compound of m.p. 90° C. (from isopropanol) are obtained.

Provenance & Evidence