HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (6S)-4-Nitrobenzyl 3-hydroxy-8-oxo-7-(N-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ozone | HCID 24823 | — |
| Reactant | HCID 70524504 | HCID 70524504 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (6S)-4-Nitrobenzyl 3-hydroxy-8-oxo-7-(N-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | HCID 67685788 | — |
Reaction Steps
A solution of 4-nitrobenzyl 7-(2-phenylacetamido)-3-acetoxymethylenecepham-4-carboxylate (1.97 g), ethyl acetate (30 ml) and methanol (7.5 ml) was treated with ozone in a similar manner to that of Example 1 (4) to give 4-nitrobenzyl 7-(2-phenylacetamido)-3-hydroxy-3cephem-4-carboxylate (400 mg.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04363807 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-62d4a1bf756a49e9bdd712f4d5f76e15 |
| Source note | uspto-grants-1982_12 |