HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → HCID 178422719, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 20515679 | HCID 20515679 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178422719 | HCID 178422719 | 21.6% |
Reaction Conditions
| Temperature | 125 °C |
|---|
Reaction Steps
A mixture of 1-(2-cyanoethyl)-2-methyl-3-(3-pyridylmethyl)indole (0.8 g), sodium azide (0.95 g), ammonium chloride (0.78 g) and dry dimethylformamide (12 ml) was heated with stirring at 125° C. for 20 hours and then evaporated. Water (25 ml) was added to the residue to dissolve inorganic material. The insoluble portion was crystallised from methanol/ethyl acetate to give 1-[2-(5-tetrazolyl)ethyl]-2-methyl-3-(3-pyridylmethyl)indole (0.20 g), m.p. 173°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04363912 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-e215f75e3b0d481394a0c49e26281d8f |
| Source note | uspto-grants-1982_12 |