Buthidazolamine → HCID 54017706, compound

HRID 1902536Notes

Reaction equation

[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[S:19][C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])=[N:21][N:22]=1>>[C:23]([C:20]1[S:19][C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)=[N:22][N:21]=1)([CH3:26])([CH3:25])[CH3:24]

Participants

Reactant 2

HCID 170170Buthidazolamine

HCID 12874874HCID 12874874, compound

Product 1

HCID 54017706HCID 54017706, compoundYield 40.6%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (18.2 g) and 2-amino-5-tert.-butyl-1,3,4-thiadiazole (15.7 g) as the starting materials, (S)-3-[(5-tert.-butyl-1,3,4-thiadiazol-2-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (7.0 g) is obtained in the form of white crystals, m.p.=137° C.

Sources & evidence

ORD record: ord-ac9d8f8f963642f6aeb0520ca5f60fd5
Source dataset: uspto-grants-1982_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04363909

Reaction notes

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