HCID 12874874, compound → HCID 178419892, compound

HRID 1902537Notes

Reaction equation

HRID 1902537 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[CH:22]=[CH:21][NH:20][N:19]=1>>[NH:20]1[CH:21]=[CH:22][C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)=[N:19]1

Participants

3

Reactant 2

HCID 12874874HCID 12874874, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 178419892HCID 178419892, compoundYield 51.7%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (18.2 g) and 3-aminopyrazole (8.3 g) as the starting materials, (S)-3-(pyrazol-3-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (7.0 g) is obtained in the form of white crystals, m.p.=161° C.

Sources & evidence

ORD record
ord-0200ecbc0fc94877b3545e3666e310eb
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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