Aminopyrazine → HCID 54031084, compound

HRID 1902540Notes

Reaction equation

HRID 1902540 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[CH:23]=[N:22][CH:21]=[CH:20][N:19]=1>>[N:19]1[CH:20]=[CH:21][N:22]=[CH:23][C:18]=1[N:17]=[C:4]1[N:8]2[CH2:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[CH2:16][C@H:7]2[CH2:6][S:5]1

Participants

3

Reactant 2

HCID 78747AminopyrazineHCID 12874874HCID 12874874, compound

Product 1

HCID 54031084HCID 54031084, compoundYield 60%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (16.3 g) and 2-aminopyrazine (8.5 g) as the starting materials, (S)-3-(pyrazin-2-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (7.6 g) is obtained in the form of white crystals, m.p.=140° C.

Sources & evidence

ORD record
ord-ce8ced9f7f74421a8df4148ca61f67bc
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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