Thieno[2,3-b]pyridin-3-amine → HCID 22822251, compound

HRID 1902542Notes

Reaction equation

HRID 1902542 reaction equation
[I-].CS[C:4]1[S:5][CH2:6][C@@H:7]2[CH2:16][C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[CH2:9][N+:8]=12.[NH2:17][C:18]1[C:26]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[S:20][CH:19]=1>>[S:20]1[C:21]2=[N:22][CH:23]=[CH:24][CH:25]=[C:26]2[C:18]([N:17]=[C:4]2[N:8]3[CH2:9][C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=4[CH2:16][C@H:7]3[CH2:6][S:5]2)=[CH:19]1

Participants

3

Reactant 2

HCID 289923Thieno[2,3-b]pyridin-3-amineHCID 12874874(S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide

Product 1

HCID 22822251HCID 22822251, compoundYield 73.9%

Procedure

By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (6.7 g) and 3-aminothieno[2,3-b]pyridine (2.8 g) as the starting materials, (S)-3-[(thieno[2,3-b]pyrid-3-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (4.6 g) is obtained in the form of beige crystals, m.p.=145°-146° C.

Sources & evidence

ORD record
ord-f5133df3213e4434bb17de3ddffca7ab
Source dataset
uspto-grants-1982_12
Patent number
US04363909

Reaction notes

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