HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminoquinoline → (S)-3-(quinol-5-yl-imino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminoquinoline | HCID 11911 | — |
| Reactant | (S)-3-Methylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide | HCID 12874874 | — |
| Product | (S)-3-(quinol-5-yl-imino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline | HCID 22822250 | 90.3% |
Reaction Steps
By following the procedure of Example 2, but using (S)-3-methylthio-1,5,10,10a-tetrahydrothiazolo-[3,4-b]isoquinolinium iodide (18.2 g) and 5-aminoquinoline (14.4 g) as the starting materials, (S)-3-(quinol-5-yl-imino)-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline (15.0 g) is obtained in the form of light beige crystals, m.p.=194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04363909 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-811fd73103f24d9fb53a677f39a7790f |
| Source note | uspto-grants-1982_12 |