HCID 53889118, compound → HCID 54016375, compound

Participants

Reaction Steps

Ethyl 5-nitroisoquinoline-3-acetate (20 g) is dissolved in ethyl acetate (1 liter), and a catalyst consisting of palladium-on-carbon (3/97 by weight; 21 g) is added. The mixture is hydrogenated at atmospheric pressure, at a temperature of about 50° C., for 2 hours. It is filtered through diatomaceous silica and the filtrate is then concentrated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) at 50° C. to yield ethyl 5-aminoisoquinoline-3-acetate (15.8 g) in the form of beige crystals, m.p.=90° C.

Provenance & Evidence