Propylene Oxide → HCID 133357, compound

Participants

Reaction Conditions

Reaction Steps

Propylene oxide (0.8 g) is added to a solution of (S)-3-[(4-carboxymethylthiazol-2-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinoline hydrochloride (0.5 g) in methanol (30 cc). The mixture is stirred for 16 hours at a temperature of the order of 20° C. The precipitate which was formed is filtered off and dried under reduced pressure (20 mm Hg; 2.7 kPa) at 40° C. to yield (S)-3-[(4-carboxymethylthiazol-2-yl)imino]-1,5,10,10a-tetrahydrothiazolo[3,4-b]-isoquinoline (0.2 g), which is a white solid, m.p.=185° C.

Provenance & Evidence