3-(Trifluoromethyl)benzylamine → HCID 20514530, compound

HRID 1902598Notes

Reaction equation

HRID 1902598 reaction equation
[Cl:1][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][C:5](OC2C=CC=CC=2)=[C:4]([N+:22]([O-:24])=[O:23])[CH:3]=1.[F:25][C:26]([F:36])([F:35])[C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30][NH2:31]>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([N+:22]([O-:24])=[O:23])[C:5]([NH:31][CH2:30][C:29]2[CH:32]=[CH:33][CH:34]=[C:27]([C:26]([F:25])([F:35])[F:36])[CH:28]=2)=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 20514529HCID 20514529, compound

Product 1

HCID 20514530HCID 20514530, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using a procedure analogous to that described in Example 12, 3 gm (71.2% of theory) of the title compound, m.p. 140°-142° C. (recrystallized from ethanol), were obtained by stirring a mixture of 3.51 gm of 6-chloro-4-nitro-1,3-diphenoxy-benzene, 4 gm of 3-trifluoromethyl-benzylamine and 5 ml of dioxane for 20 hours at 100° C.

Workup

  1. customthat described in Example 12, 3 gm (71.2% of theory) of the title compound, m.p. 140°-142° C. (recrystallized from ethanol)
  2. customwere obtained

Sources & evidence

ORD record
ord-c915b2a9fab14ee3a2598c9238ba47ae
Source dataset
uspto-grants-1982_12
Patent number
US04364875

Reaction notes

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