HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-[(5-Nitro-1,3-benzothiazol-2(3H)-ylidene)amino]ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(2-Chloro-5-nitrophenyl)-N'-(2-hydroxyethyl)carbamimidothioic acid | HCID 3018768 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-[(5-Nitro-1,3-benzothiazol-2(3H)-ylidene)amino]ethan-1-ol | HCID 3018769 | 82% |
Reaction Steps
A mixture of 28 parts of N-(2-chloro-5-nitrophenyl)-N'-(2-hydroxyethyl)thiourea, 14.5 parts of potassium carbonate and 225 parts of N,N-dimethylformamide is stirred and refluxed for one hour. After cooling, 300 parts of water are added. The precipitated product is filtered off, washed with water and dried, yielding 20.5 parts (82%) of 2-[(5-nitro-2-benzothiazolyl)amino]ethanol; mp. 183.4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04364942 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-fbd968128ff04f6180ef718f492c5fb6 |
| Source note | uspto-grants-1982_12 |