Sodium Iodide → HCID 13277730, compound

Participants

Reaction Steps

Freshly distilled chloroacetone (31 ml) was added to a solution of sodium iodide (1.0 g) in dry acetone (50 ml). The mixture was allowed to stand for 1 hour at room temperature and then added over 1 hour to a stirred, refluxing mixture of 4-(cyclohexyl)phenol (52.8 g) and anhydrous potassium carbonate (52 g) in dry acetone (100 ml). The stirred mixture was heated under reflux for a further 5 hours, filtered and evaporated to a brown oil which crystallised from ether-petroleum spirit (40°-60° C.) to give 1-[4-(cyclohexyl)phenoxy]-2-propanone (mp 58° C.).

Provenance & Evidence