Acetic Anhydride → HCID 20514654, compound

Participants

Reaction Steps

3.39 g. (0.01 mole) of 2-cyclohexyl-sulfonyl-4-phenylamino-4-oxo-butanoic acid are dissolved in 20 ml. of acetic acid anhydride and 0.82 g. (0.01 mole) anhydrous sodium acetate and the solution is heated for 1 hour at 100° C. The reaction mixture is then poured on crushed ice and the precipitated compound named filtered off and washed with water in order to remove acid. 2.76 g. (86%) of the named compound are obtained. M.p.: 149°-151° C. After recrystallization from methanol m.p.: 150°-152° C. Minimal inhibitory concentration inhibiting the growth of Trychophyton mentagrophytes: 2.5 μg/ml. and of Epidermophyton floccosum: 1.0 μg./ml.

Provenance & Evidence