Methyl iodide → Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

HRID 1902766Notes

Reaction equation

HRID 1902766 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:21]I>N1C=CC=CC=1>[CH3:21][NH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20515218Ethyl 3-amino-4-cyclohexylphenylglyoxylate

Product 1

HCID 20515175Ethyl 3-methylamino-4-cyclohexylphenylglyoxylate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a solution of 0.01 moles of ethyl 3-amino-4-cyclohexylphenylglyoxylate in 100 ml. of pyridine is added 0.1 moles of methyl iodide. The reaction mixture is stirred overnight at room temperature, filtered and concentrated. The residue is distilled to obtain ethyl 3-methylamino-4-cyclohexylphenylglyoxylate.

Workup

  1. filtrationfiltered
  2. concentrationconcentrated
  3. distillationThe residue is distilled

Sources & evidence

ORD record
ord-9ced04c6fda84fd0bc5810072dc7ed8f
Source dataset
uspto-grants-1982_12
Patent number
US04365093

Reaction notes

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