Hydrochloric Acid → HCID 20514849, compound

Participants

Reaction Steps

A solution of 2-benzhydryloxycarbonyl-3-(2-dimethylaminovinyl)-8-oxo-7-tritylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene (E-form) (23.5 g) in ethyl acetate (500 cc) is stirred with 1 N hydrochloric acid (250 cc) for 90 minutes at 25° C. The organic phase is decanted, washed with distilled water (3×250 cc), a saturated sodium bicarbonate solution (100 cc) and a half-saturated sodium chloride solution (250 cc), then dried over sodium sulphate and concentrated to dryness under reduced pressure (40 mm Hg) at 40° C. 2-Benzhydryloxycarbonyl-8-oxo-3-(2-oxo-ethyl)-7-tritylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene (21 g) is obtained in the form of an orange-coloured froth.

Provenance & Evidence