Sodium Iodide → HCID 20455144, compound

Participants

Reaction Steps

163.4 g of 1-(2-chloroethyl)-2-nitroimidazole and 200.4 g of sodium iodide were heated under reflux for 4.5 hours in 1 liter of ethyl methyl ketone. After cooling, the mixture was filtered, the solvent was evaporated off, the residue was partitioned between 2 liters of dichloromethane and 1 liter of water and the organic phase was washed twice with 1 liter of water each time and evaporated. Crystallization from 1 liter of isopropanol yielded 206 g of 1-(2-iodoethyl)-2-nitroimidazole, m.p. 79°-82° C.

Provenance & Evidence