Sodium Chloride → HCID 13083939, compound

Participants

Reaction Steps

9 ml. of an aqueous solution containing 0.70 g (0.0174 mol) of sodium hydroxide is added and the solution obtained in Step A, above, stirred for 7 hours. Sodium chloride is added to saturate the aqueous solution followed by 100 ml. of diethyl ether. The solution is agitated, the layers partitioned, and the ethereal solution is dried over anhydrous sodium sulfate. The solution is concentrated in vacuo to afford a yellow oil. After drying on a vacuum pump for 3 hours, the oily solid is recrystallized from 300 ml. of a hot mixture of hexane isomers. The resulting solid is recrystallized from 100 ml. of hot hexanes to afford the title product, {8-[3-(4-methoxyphenoxy)propyl]-3-hydroxy-8-azabicyclo-[3.2.1]oct-3-yl}-4-fluorophenyl methanone; m.p. 100°-101° C.

Provenance & Evidence