Sodium borohydride → HCID 12711983, compound

Participants

Reaction Steps

A suspension of 4.0 g. (0.016 mole) of 4-dimethylamino-4-(p-chlorophenyl)cyclohexanone in 60 ml. 95% isopropanol is warmed to dissolve the solid. Sodium borohydride (0.61 g.) is then added and the mixture stirred at room temperature for six hours. The bulk of the solvent is then removed in vacuum. The residue is taken up in water and methylene chloride. The organic layer is washed with water and brine and taken to dryness. The residual solid is recrystallized twice from acetone to afford 1.21 g. (30%) of product, melting point 148°-150.5° C.

Provenance & Evidence