HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorophenyl isothiocyanate → HCID 20513898, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorophenyl isothiocyanate | HCID 4031601 | — |
| Reactant | N-{2-[(benzyloxy)amino]ethyl}phthalimide | HCID 18787878 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20513898 | HCID 20513898 | — |
Reaction Steps
A solution of 19.68 g of 2,6-difluorophenylisothiocyanate and 34.1 g of N-{2-[N-(benzyloxy)amino]ethyl}phthalimide in 150 ml of benzene is heated to boiling under reflux for 6 hours. The cooled solution is separated from a slight precipitate and then evaporated in vacuo. The residual oil crystallizes from isopropyl ether. There is obtained 1-(benzyloxy)-3-(2,6-difluorophenyl)-1-(2-phthalimidoethyl)-2-thiourea of melting point 141°-143° (ether/methylene chloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04366160 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-6a68f3bbdd1e4d8f97c16e54e8fc6437 |
| Source note | uspto-grants-1982_12 |