2-(Chloromethyl)pyridine 1-oxide → HCID 178478899, compound

HRID 1902863Notes

Reaction equation

HRID 1902863 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[OH:15].[Cl:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N+:19]=1[O-:24].CC(C)=O.[ClH:29]>O1CCOCC1>[ClH:16].[ClH:29].[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[O:15][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N+:19]=1[O-:24]

Participants

5

Reactant 3

HCID 2655032-(Chloromethyl)pyridine 1-oxideHCID 19044839Acetone hydrogen chlorideHCID 178526277HCID 178526277, compound

Product 1

HCID 178478899HCID 178478899, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 2-[(2,6-difluorophenyl)imino]-1-hydroxy-imidazolidine and 2-chloromethyl-pyridine N-oxide there is obtained, in analogy to the details in Example 1,2-([{2-[(2,6-difluorophenyl)imino]-1-imidazolidinyl}oxy]methyl)-pyridine 1-oxide dihydrochloride of melting point 188°-189° (acetone/hydrogen chloride in dioxane).

Sources & evidence

ORD record
ord-d75679cb844e4f339e7e79ce8ebfba31
Source dataset
uspto-grants-1982_12
Patent number
US04366160

Reaction notes

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