HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 1,3-Dichloro-4-methoxy-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,4-Dichloro-3-nitrophenol | HCID 20513932 | — |
| Catalyst | Benzyltrimethylammonium chloride | HCID 5963 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,3-Dichloro-4-methoxy-2-nitrobenzene | HCID 20513886 | — |
Reaction Steps
A solution of 155.4 g of 2,4-dichloro-3-nitrophenol in 2 l of methylene chloride is treated with 16.9 g of benzyltrimethylammonium chloride. There is added thereto a solution of 44.8 g of sodium hydroxide in 1.8 l of water and, while stirring vigorously, 143 ml of dimethyl sulfate. After 1 hour, the organic phase is separated, washed with water, dried and evaporated in vacuo. There is obtained 2,4-dichloro-3-nitroanisole of melting point 97°-99° (hexane).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04366160 |
| Source dataset | uspto-grants-1982_12 |
| ORD ID | ord-b4b0d6bc19a14b90a43aaa7fe88e31f1 |
| Source note | uspto-grants-1982_12 |