Formic Acid → Diisopropyl Ether

Participants

Reaction Steps

2.3 g of 2-([{2-[(2,5-dichlorophenyl)-imino]-1-imidazolidinyl}oxy]methyl)pyridine and 5.1 ml of formic acid are cooled to 5° and treated with 12.2 ml of acetic acid anhydride. The solution is warmed to room temperature and evaporated in vacuo. The residue is taken up in ether. The organic phase is washed with a saturated sodium bicarbonate solution, dried and evaporated in vacuo. The residual of oil is chromatographed on silica gel with a mixture of 4 parts of chloroform and 1 part of ethyl acetate as the elution agent. There is obtained crystalline 2-[(2,5-dichlorophenyl)amino]-1-formyl-3-(2-pyridylmethoxy)imidazolidine of melting point 91°-92° (isopropyl ether).

Provenance & Evidence