Phenol → HCID 20514081, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 250 g of phenol and 29.7 g of sodium methylate is heated to an interval temperature of 160° C. while simultaneously distilling off methanol. The melt obtained is cooled to 120° C., then 109 g of 4-chloro-6-methyl-2-p-tolylpyrimidine are added and the mixture is stirred for 3 hours at 120° C. After cooling, excess phenol is removed with steam, and the residue is filtered with suction, washed with water and dried. Recrystallisation from methanol yields 119.4 g (86.5% of theory) of 4-methyl-6-phenoxy-2-p-tolylpyrimidine with a melting point of 90°-91° C.

Provenance & Evidence